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Drug release and antimicrobial property of Cellulose Nanofibril/β-Cyclodextrin/Sulfadiazine films

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Abstract

Active Principal Ingredient (API) encapsulation through adsorption and physical entrapment onto TEMPO-oxidized cellulose nanofibrils (toCNFs) is possible, but challenges such as burst release and use of low water-soluble API such as sulfadiazine (SD) are yet to be addressed. The objective of this study is to assess the release property and antibacterial activity of toCNF/β-Cyclodextrin (β-CD)/SD materials in the form of films. Release in sink conditions was achieved with result highlighting the importance of the toCNF network structure, which is tightened at acidic pH for toCNFs due to its carboxylic content, reducing the burst effect phenomena. Antibacterial activity against Staphylococcus aureus and Escherichia coli was assessed and the results showed a clear beneficial impact of using β-CDs. An antibacterial effect for toCNF/SD films is confirmed for 3 successive applications whereas an antibacterial effect for a toCNF/CMβCD/SD film is prolonged up to 7 successive applications. The improvement of the topical release of a prophylactic agent with these materials are making them promising for biomedical applications such as wound dressing.

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Acknowledgments

The authors acknowledge the French National Research Agency in the framework of the "Investissements d’avenir” program Glyco@Alps (ANR-15-IDEX-02) and NTNU through its Department of Chemical Engineering for funding this work, and LGP2 and its employees for the help and support given to this project.

Funding

This work is supported by the French National Research Agency in the framework of the "Investissements d’avenir” program Glyco@Alps (ANR-15-IDEX-02) and NTNU through its Department of Chemical Engineering. LGP2 is part of the LabEx Tec 21 (Investissements d’Avenir—Grant Agreement No. ANR-11-LABX-0030) and of the PolyNat Carnot Institute (Investissements d’Avenir—Grant Agreement No. ANR-16-CARN-0025–01).This research was made possible thanks to the facilities of the TekLiCell platform funded by the Région Rhône-Alpes (ERDF: European regional dsevelopment fund).

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BM: Investigation, Methodology, Writing—Original Draft, Editing. EBH: Conceptualization, Methodology, Supervision, Reviewing and Editing. CS: Methodology. KS: Conceptualization, Methodology, Supervision, Reviewing and Editing. AD: Conceptualization, Methodology, Supervision, Reviewing and Editing. JB: Conceptualization, Methodology, Supervision, Reviewing and Editing.

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Correspondence to Julien Bras.

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The authors declare no competing interests.

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Michel, B., Heggset, E.B., Sillard, C. et al. Drug release and antimicrobial property of Cellulose Nanofibril/β-Cyclodextrin/Sulfadiazine films. Cellulose 30, 4387–4400 (2023). https://doi.org/10.1007/s10570-023-05135-6

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  • DOI: https://doi.org/10.1007/s10570-023-05135-6

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